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Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy.
Angew Chem Int Ed Engl ; 58(40): 14213-14218, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31347259
ABSTRACT
Covalent organic frameworks (COFs) with 2D π-conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules, 5',5''''-(1,4-phenylene)bis(([1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde)) (L-3C) and 4,4',4''-(1,4-phenylene)bis(([2,2':6',2''-terpyridine]-5,5''-dicarbaldehyde)) (L-3N), inactive to generating reactive oxygen species (ROS), were linked to form two COFs, COF-808 and COF-909, respectively, exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs (surface areas 2270 and 2610 m2 g-1 ) promoted diffusion of both oxygen and release of ROS in cells. This, combined with the excellent photostability and biocompatibility, led to excellent PDT performance. In vitro, over 80 % of tumor cells were killed after PDT treatment using COF-909 at the concentration of 50 µg mL-1 for 150 s. In vivo, drastic reduction of tumor size was observed (from 9 mm to less than 1 mm) after 10 day treatment.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China