Metabotropic glutamate receptor 5 (mGlu<sub>5</sub> )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu<sub>5</sub> signaling in recombinant cells and neurons.

Hellyer, Shane D; Albold, Sabine; Sengmany, Kathy; Singh, Junaid; Leach, Katie; Gregory, Karen J

Metabotropic glutamate receptor 5 (mGlu₅ )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu₅ signaling in recombinant cells and neurons.

Hellyer, Shane D; Albold, Sabine; Sengmany, Kathy; Singh, Junaid; Leach, Katie; Gregory, Karen J.

Afiliação

Hellyer SD; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
Albold S; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
Sengmany K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
Singh J; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
Leach K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.
Gregory KJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia.

J Neurochem ; 151(3): 301-315, 2019 11.

Article em En | MEDLINE | ID: mdl-31376155

Assuntos

Receptor de Glutamato Metabotrópico 5/efeitos dos fármacos; Regulação Alostérica/efeitos dos fármacos; Animais; Benzamidas/farmacologia; Corpo Estriado/efeitos dos fármacos; Corpo Estriado/metabolismo; Humanos; Camundongos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Oxazóis/farmacologia; Ácidos Picolínicos/farmacologia; Piridinas/farmacologia; Receptor de Glutamato Metabotrópico 5/metabolismo

Palavras-chave

biased modulation; context dependence; desensitization; metabotropic glutamate receptor 5; positive allosteric modulator

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor de Glutamato Metabotrópico 5 Limite: Animals / Humans Idioma: En Revista: J Neurochem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido

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