Your browser doesn't support javascript.
loading
Multifunctional Cosmetic Containing Blueberry and Tinosorb M®-Loaded Microparticles Improves Sunscreen Performance.
Schiavon, Daiana; Martini, Daniela Novello; Brocco, Gabriela; Santos, Júlia Scherer; Anzolin, Ana Paula; Rossato-Grando, Luciana Grazziotin; Omidian, Hamid; Bertol, Charise Dallazem.
Afiliação
  • Schiavon D; Curso de Farmácia, Universidade de Passo Fundo, Passo Fundo, Brasil.
  • Martini DN; Curso de Farmácia, Universidade de Passo Fundo, Passo Fundo, Brasil.
  • Brocco G; Curso de Farmácia, Universidade de Passo Fundo, Passo Fundo, Brasil.
  • Santos JS; Curso de Farmácia, Centro Universitário União Dinâmica das Cataratas, Foz do Iguaçu, Paraná, Brasil.
  • Anzolin AP; Programa de Pós-Graduação em Envelhecimento Humano, Universidade de Passo Fundo, Passo Fundo, Brasil.
  • Rossato-Grando LG; Curso de Farmácia, Universidade de Passo Fundo, Passo Fundo, Brasil.
  • Omidian H; Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, Passo Fundo, Brasil.
  • Bertol CD; Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Adv Pharm Bull ; 9(2): 241-248, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31380249
ABSTRACT

Purpose:

We aimed to evaluate the effect of blueberry extract and microparticles (MP) on sunscreen performance of multifunctional cosmetics. Octocrylene (OCT), benzophenone-3 (BENZ-3) and Tinosorb® M (MBBT) were employed as UV filters.

Methods:

An in-silico modeling was used to determine the UV filters concentrations to obtain high values of sunscreen protection factor (SPF) and UVA protection factor (UVA-PF). MBBT and blueberry-loaded microparticles (MPMB+B) and MBBT-loaded microparticles (MPMBBT) were prepared by spray-drying. OCT and BENZ-3 were added in the oil phase of cosmetics. Cosmetics A and B contained MPMB+B and MPMBBT, respectively, and cosmetic C was prepared without MP. Characterization, physicochemical stability and in vitro SPF was performed. UV filters distribution in human stratum corneum (SC) for each cosmetic was performed. Anti-oxidant activity of blueberry extract was evaluated.

Results:

Sunscreen combination with the highest SPF was selected for formulations. Formulations A and B maintained their rheological behavior over time, unlike formulation C. In-vitro SPFs for formulations A, B and C were 51.0, 33.7 and 49.6, respectively. We also developed and validated a method for analysis of the UV filters by HPLC/ PDA suitable for the in-vivo assay. In Tape stripping test, MBBT showed SC distribution similar for all cosmetic formulations. OCT and BENZ-3 distribution to formulation A and C was also similar. Blueberry extract showed antioxidant capacity of 16.71 µg/mL equivalent to vitamin C.

Conclusion:

Cosmetics containing MPs presented better physical stability. Blueberry increased the photoprotective capacity of the formulations and added extra benefits due to its anti-oxidant and anti-aging properties.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Adv Pharm Bull Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Adv Pharm Bull Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil