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Probiotic strategies to prevent necrotizing enterocolitis in preterm infants: a meta-analysis.
Pediatr Surg Int ; 35(10): 1143-1162, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31420743
ABSTRACT

PURPOSE:

We aimed to compare probiotics with placebo for necrotizing enterocolitis in preterm infants and to evaluate the safety and effect and strict effect of specific probiotic genera.

METHODS:

Data recorded until January 2019 were searched, and relevant academic articles from PubMed, MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were selected by two independent reviewers. Two reviewers independently included randomized controlled trials that compared probiotics and placebo in preterm infants. The outcomes included more than one of the following

outcomes:

incidence of necrotizing enterocolitis, necrotizing enterocolitis-related mortality, incidence of sepsis, and all-cause mortality. Two reviewers independently extracted data and assessed the risk of bias and quality of evidence.

RESULTS:

We identified 34 eligible studies of 9161 participants. This meta-analysis showed an overall advantage of probiotics to prevent the incidence of necrotizing enterocolitis (3.54%) and gut-associated sepsis (15.59%), and decrease mortality (5.23%) in preterm infants. A probiotic mixture showed a huge advantage and vitality in preventing necrotizing enterocolitis (2.48%) and gut-associated sepsis (18.39%), and in reducing mortality (5.57%) in preterm infants.

CONCLUSION:

The probiotic mixture showed advantages over the single strains to decrease the incidences of necrotizing enterocolitis and gut-associated sepsis, and mortality in preterm infants.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Recém-Nascido Prematuro / Guias de Prática Clínica como Assunto / Probióticos / Enterocolite Necrosante / Doenças do Prematuro Tipo de estudo: Ensaio clínico controlado / Guia de prática clínica / Revisão sistemática Aspecto clínico: Etiologia / Prognóstico Limite: Humanos / Recém-Nascido Idioma: Inglês Revista: Pediatr Surg Int Assunto da revista: Pediatria Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China