Focused transcranial ultrasound for treatment of neurodegenerative dementia.
Alzheimers Dement (N Y)
; 5: 374-381, 2019.
Article
em En
| MEDLINE
| ID: mdl-31440580
ABSTRACT
INTRODUCTION:
Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).METHODS:
A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm2) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 patients (n = 11 AD, n = 11 PD) underwent 8 consecutive, weekly, 1-hour treatments wherein sleep was encouraged naturally or pharmacologically. Cognitive and motor functioning assessment was carried out using standardized evaluations at baseline and conclusion.RESULTS:
Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported.DISCUSSION:
The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Alzheimers Dement (N Y)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá