Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives.

Rafiq, Muhammad; Nazir, Yasir; Ashraf, Zaman; Rafique, Hummera; Afzal, Samina; Mumtaz, Amara; Hassan, Mubashir; Ali, Anser; Afzal, Khurram; Yousuf, Muhammad Rizwan; Saleem, Muhammad; Kotwica-Mojzych, Katarzyna; Mojzych, Mariusz

Rafiq, Muhammad; Nazir, Yasir; Ashraf, Zaman; Rafique, Hummera; Afzal, Samina; Mumtaz, Amara; Hassan, Mubashir; Ali, Anser; Afzal, Khurram; Yousuf, Muhammad Rizwan; Saleem, Muhammad; Kotwica-Mojzych, Katarzyna; Mojzych, Mariusz.

Afiliação

Rafiq M; Department of Physiology & Biochemistry, Cholistan University of Veterinary and Animal Sciences , Bahawalpur, Punjab , Pakistan.
Nazir Y; Department of Chemistry, Allama Iqbal Open University , Islamabad , Pakistan.
Ashraf Z; Department of Chemistry, Allama Iqbal Open University , Islamabad , Pakistan.
Rafique H; Department of Chemistry, University of Gujrat , Gujrat , Pakistan.
Afzal S; Faculty of Pharmacy, Bahauddin Zakria University , Multan , Pakistan.
Mumtaz A; Department of Chemistry, COMSAT University Islamabad , Abbottabad , Pakistan.
Hassan M; Department of Biology, College of Natural Sciences, Kongju National University , Gongju , Korea.
Ali A; Department of Zoology, Mirpur University of Science and Technology (MUST) , Mirpur , Pakistan.
Afzal K; Faculty of Pharmacy, Bahauddin Zakria University , Multan , Pakistan.
Yousuf MR; Department of Theriogenology, University of Veterinary and Animal Sciences , Lahore , Pakistan.
Saleem M; Department of Chemistry, University of Sargodha , Bhakkar , Pakistan.
Kotwica-Mojzych K; Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin , Lublin , Poland.
Mojzych M; Department of Chemistry, Siedlce University of Natural Sciences and Humanities , Siedlce , Poland.

J Enzyme Inhib Med Chem ; 34(1): 1-11, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31456445

Assuntos

Antineoplásicos/farmacologia; Inibidores Enzimáticos/farmacologia; Radical Hidroxila/farmacologia; Melanoma/tratamento farmacológico; Monofenol Mono-Oxigenase/antagonistas & inibidores; Fenóis/farmacologia; Animais; Antineoplásicos/síntese química; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Radical Hidroxila/síntese química; Radical Hidroxila/química; Cinética; Melanoma/metabolismo; Melanoma/patologia; Camundongos; Modelos Moleculares; Estrutura Molecular; Monofenol Mono-Oxigenase/metabolismo; Fenóis/síntese química; Fenóis/química; Relação Estrutura-Atividade; Células Tumorais Cultivadas

Palavras-chave

Tyrosinase inhibition; antimelanogenic activity; cytotoxicity; enzyme inhibitory kinetics; molecular docking

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Monofenol Mono-Oxigenase / Radical Hidroxila / Inibidores Enzimáticos / Melanoma / Antineoplásicos Limite: Animals Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Reino Unido

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