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Canalostomy is an ideal surgery route for inner ear gene delivery in big animal model.
Acta Otolaryngol ; 139(11): 939-947, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31486693
ABSTRACT

Background:

Inner gene therapy offers great promises as a potential treatment for hearing loss. Aims/

objectives:

One of the critical determinants of the success of inner ear gene therapy is to find a delivery method which results in consistent transduction efficiency of targeted cell types while minimizing hearing loss. Material and

methods:

Surgery was performed only in the right ear of each Bama miniature pig, and the left ear served as a control. The gene delivery to inner ear via round window membrane (RWM) and posterior semicircular canal (PSC) approach was performed with the viral vector AAV1-CMV-GFP.

Results:

The gene delivery through RWM and the PSC (canalostomy) is able to perfuse the inner ear. Conclusions and

significance:

The easy anatomic identification of the PSC, as to RWM, as well as minimal manipulation of the temporal bone required, make this surgical approach an attractive option for inner ear gene delivery in big animal model.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Acta Otolaryngol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China