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Malnutrition Predisposes to Endotoxin-Induced Edema and Impaired Inflammatory Response in Parenterally Fed Piglets.
Baek, Ole; Fabiansen, Christian; Friis, Henrik; Ritz, Christian; Koch, Jørgen; Willesen, Jakob L; Heegaard, Peter M H; Lykkesfeldt, Jens; Briend, André; Golden, Michael H; Sangild, Per T; Thymann, Thomas.
Afiliação
  • Baek O; Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.
  • Fabiansen C; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  • Friis H; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  • Ritz C; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  • Koch J; Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Willesen JL; Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Heegaard PMH; Innate Immunology Group, National Veterinary Institute, Technical University of Denmark, Copenhagen, Denmark.
  • Lykkesfeldt J; Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.
  • Briend A; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  • Golden MH; University of Tampere School of Medicine and Tampere University Hospital, University of Tampere, Tampere, Finland.
  • Sangild PT; Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK.
  • Thymann T; Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.
JPEN J Parenter Enteral Nutr ; 44(4): 668-676, 2020 05.
Article em En | MEDLINE | ID: mdl-31512266
ABSTRACT

BACKGROUND:

Poor nutrition status is common among hospitalized children and children in low-income countries and may be associated with increased susceptibility to edema and infections. We hypothesized that poor nutrition status, established with a suboptimal composition of parenteral nutrition (PN), predisposes to endotoxemia-induced edema, oxidative stress, and dysregulated immune responses.

METHODS:

Using a 2 × 2 factorial design, 3-day-old piglets (n = 40) were given either optimal or suboptimal composition of PN for 7 days and then infused with either saline or lipopolysaccharide (LPS) for 9 hours to induce an acute-phase reaction. Abdominal tissue edema and blood markers of immunity, inflammation, and oxidative stress were assessed.

RESULTS:

Piglets receiving suboptimal nutrition showed signs of malnutrition with restricted growth, signs of inflammation (elevated C-reactive protein [CRP], interleukin-6, and serum amyloid A levels), oxidative stress (lower erythrocyte glutathione/hemoglobin and α-tocopherol/cholesterol ratios), and liver dysfunction (increased liver weight and blood bilirubin levels). Perirenal edema was more excessive in malnourished LPS-infused animals, relative to healthy LPS-infused control animals (P < .01). Malnutrition reduced the inflammatory response to LPS (lower CRP, tumor necrosis factor-α, haptoglobin, and neutrophil to lymphocyte ratio) but did not influence LPS-induced oxidative stress markers.

CONCLUSIONS:

We conclude that endotoxemia and malnutrition in combination lead to acute-phase hyporesponsiveness and perirenal edema in piglets. This finding may have implications for pediatric patients that suffer from malnutrition, as their response to bacterial infections may differ substantially from patients of normal nutrition status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nutrição Parenteral / Desnutrição / Edema / Endotoxinas Tipo de estudo: Etiology_studies Aspecto: Determinantes_sociais_saude Limite: Animals / Child / Humans Idioma: En Revista: JPEN J Parenter Enteral Nutr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nutrição Parenteral / Desnutrição / Edema / Endotoxinas Tipo de estudo: Etiology_studies Aspecto: Determinantes_sociais_saude Limite: Animals / Child / Humans Idioma: En Revista: JPEN J Parenter Enteral Nutr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA