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Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
Yamada, Daisuke; Kawabe, Kenji; Tosa, Ikue; Tsukamoto, Shunpei; Nakazato, Ryota; Kou, Miki; Fujikawa, Koichi; Nakamura, Saki; Ono, Mitsuaki; Oohashi, Toshitaka; Kaneko, Mari; Go, Shioi; Hinoi, Eiichi; Yoneda, Yukio; Takarada, Takeshi.
Afiliação
  • Yamada D; 1Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
  • Kawabe K; 1Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
  • Tosa I; 1Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
  • Tsukamoto S; 1Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
  • Nakazato R; 2Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192 Japan.
  • Kou M; 2Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192 Japan.
  • Fujikawa K; 2Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192 Japan.
  • Nakamura S; 2Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192 Japan.
  • Ono M; 3Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
  • Oohashi T; 3Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
  • Kaneko M; 4Laboratory for Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, 2-2-3 Minatojima Minami, Chuou-ku, Kobe, Hyogo 650-0047 Japan.
  • Go S; 4Laboratory for Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, 2-2-3 Minatojima Minami, Chuou-ku, Kobe, Hyogo 650-0047 Japan.
  • Hinoi E; 2Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192 Japan.
  • Yoneda Y; 2Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192 Japan.
  • Takarada T; 1Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
Commun Biol ; 2: 346, 2019.
Article em En | MEDLINE | ID: mdl-31552299
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Fármacos Neuroprotetores / Sistema A de Transporte de Aminoácidos / Serina-Treonina Quinases TOR Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Commun Biol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Fármacos Neuroprotetores / Sistema A de Transporte de Aminoácidos / Serina-Treonina Quinases TOR Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Commun Biol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido