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The ongoing D-lemma of vitamin D supplementation for nonskeletal health and bone health.
Curr Opin Endocrinol Diabetes Obes ; 26(6): 301-305, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31644469
ABSTRACT

PURPOSE OF REVIEW:

The goal of this review is to give some perspective on the results and conclusions of three recent randomized controlled vitamin D intervention studies that have challenged the health benefit of vitamin D supplementation for reducing risk for cardiovascular disease, cancer, all-cause mortality and type 2 diabetes and improving bone health.

RECENT FINDINGS:

Vitamin D supplementation to adults who were vitamin D sufficient or insufficient did not reduce risk for developing cardiovascular disease, cancer, type 2 diabetes nor increases bone mineral density (BMD). Patients who were vitamin D deficient with cancer and received vitamin D reduced risk for mortality by 25% and prediabetic adults who were vitamin D deficient and received vitamin D reduced their risk of developing type 2 diabetes by 62%. Older adults receiving 4000 and 10 000 IUs of vitamin D3 daily for 3 years had reduced radial BMD but had no change in either total hip areal bone density or bone strength in the radius and tibia.

SUMMARY:

Caution is needed when evaluating results and conclusions from randomized controlled trials that investigate health benefits of vitamin D; most studies suggest health benefits when vitamin D supplementation is provided to vitamin D deficient populations and little benefit when given to populations that are vitamin D sufficient/insufficient.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Aspecto clínico: Etiologia Idioma: Inglês Revista: Curr Opin Endocrinol Diabetes Obes Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Estados Unidos