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Influence of Genetic Interactions on Polygenic Prediction.
G3 (Bethesda) ; 10(1): 109-115, 2020 01 07.
Artigo em Inglês | MEDLINE | ID: mdl-31649046
ABSTRACT
Prediction of phenotypes from genotypes is an important objective to fulfill the promises of genomics, precision medicine and agriculture. Although it's now possible to account for the majority of genetic variation through model fitting, prediction of phenotypes remains a challenge, especially across populations that have diverged in the past. In this study, we designed simulation experiments to specifically investigate the role of genetic interactions in failure of polygenic prediction. We found that non-additive genetic interactions can significantly reduce the accuracy of polygenic prediction. Our study demonstrated the importance of considering genetic interactions in genetic prediction.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Aspecto clínico: Predição / Prognóstico Idioma: Inglês Revista: G3 (Bethesda) Ano de publicação: 2020 Tipo de documento: Artigo