Your browser doesn't support javascript.
loading
Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study.
Carlotto, Silvia; Bonna, Arkadiusz; Bossak-Ahmad, Karolina; Bal, Wojciech; Porchia, Marina; Casarin, Maurizio; Tisato, Francesco.
Afiliação
  • Carlotto S; Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131 Padova, Italy. silvia.carlotton@unipd.it.
  • Bonna A; Department of Biochemistry, University of Cambridge, Tennis Court Road, CB2 1QW, Cambridge, UK.
  • Bossak-Ahmad K; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland. wbal@ibb.waw.pl.
  • Bal W; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland. wbal@ibb.waw.pl.
  • Porchia M; ICMATE-CNR, Corso Stati Uniti 4, 35127 Padova, Italy. francesco.tisato@cnr.it.
  • Casarin M; Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131 Padova, Italy. silvia.carlotton@unipd.it.
  • Tisato F; ICMATE-CNR, Corso Stati Uniti 4, 35127 Padova, Italy. francesco.tisato@cnr.it.
Metallomics ; 11(11): 1800-1804, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31657408
ABSTRACT
Model peptides relevant to hCtr1 transchelate CuI from the anti-tumour [CuI(PTA)4]+ complex before metal internalization into tumor cells. ESI(+)MS experiments corroborated by DFT calculations indicate that tetracoordinated-CuII and linear-CuI arrangements of in situ generated copper-peptide products play a crucial role in promoting the transfer of copper from the terminal MDH portion into adjacent HSH peptide sequence.

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Metallomics Assunto da revista: Bioquímica Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Itália