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Polimorfnye markery nekotorykh genov v razvitii sukhogo keratokon''iunktivita u patsientov s revmatoidnym artritom i sindromom Shegrena. / [Polymorphic markers of certain genes in the development of dry keratoconjunctivitis in patients with rheumatoid arthritis and Sjogren's syndrome].
Vestn Oftalmol ; 135(5. Vyp. 2): 254-259, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31691669
The article reviews literature on relationships between polymorphic variants of the genes THBS1, GTF2I, MUC1, TRIM21, STAT4, PTPN22 with clinical features of dry keratoconjunctivitis in rheumatoid arthritis and Sjogren's syndrome. The development and implementation of a method for analyzing polymorphic gene variants used to diagnose dry keratoconjunctivitis in rheumatoid arthritis and Sjogren's syndrome will allow assessment of the possibility of developing dry keratoconjunctivitis and/or its progression in patients with autoimmune diseases or in people at risk. Determination of clinical and morphological regularities of dry keratoconjunctivitis in accordance with the revealed molecular and genetic changes will contribute to better understanding of the etiology and pathogenesis of ophthalmological manifestations of autoimmune diseases, and will also help improve the diagnostics and prognosis of dry keratoconjunctivitis.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Síndrome de Sjogren / Ceratoconjuntivite Aspecto clínico: Etiologia / Prognóstico Limite: Humanos Idioma: Russo Revista: Vestn Oftalmol Ano de publicação: 2019 Tipo de documento: Artigo