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Epidemiology of Hematologic Malignancies in Real-World Settings: Findings From the Hemato-Oncology Latin America Observational Registry Study.
Tietsche de Moraes Hungria, Vania; Chiattone, Carlos; Pavlovsky, Miguel; Abenoza, Lina M; Agreda, Gladys P; Armenta, Jorge; Arrais, Celso; Avendaño Flores, Oscar; Barroso, Fernando; Basquiera, Ana L; Cao, Carmen; Cugliari, Maria S; Enrico, Alicia; Foggliatto, Laura M; Galvez, Kenny M; Gomez, David; Gomez, Alvaro; de Iracema, Daniel; Farias, Danielle; Lopez, Lineth; Mantilla, William Armando; Martínez, Deborah; Mela, Maria Jose; Miguel, Carlos E; Ovilla, Roberto; Palmer, Luis; Pavlovsky, Carolina; Ramos, Christian; Remaggi, Guillermina; Santucci, Rodrigo; Schusterschitz, Sergio; Sossa, Claudia Lucia; Tuna-Aguilar, Elena; Vela, Jorge; Santos, Telma; de la Mora, Odin; Machnicki, Gerardo; Fernandez, Mariana; Barreyro, Paula.
Afiliação
  • Tietsche de Moraes Hungria V; Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.
  • Chiattone C; Faculdade de Ciencias Médicas-Santa Casa de São Paulo, São Paulo, Brazil.
  • Pavlovsky M; FUNDALEU, Buenos Aires, Argentina.
  • Abenoza LM; Fundacion Santa Fe de Bogotá, Bogotá, Colombia.
  • Agreda GP; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Armenta J; ISSEMYM, Mexico City, Mexico.
  • Arrais C; Hospital Sìrio-Libanês, São Paulo, Brazil.
  • Avendaño Flores O; Medical Solution SA, Guatemala City, Guatemala.
  • Barroso F; Hospital Universitario Walter Cantidio, Fortaleza, Brazil.
  • Basquiera AL; Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina.
  • Cao C; Instituto Nacional del Cancer, Santiago, Chile.
  • Cugliari MS; Instituto de Oncología Ángel H. Roffo, Buenos Aires, Argentina.
  • Enrico A; Hospital Italiano La Plata, Buenos Aires, Argentina.
  • Foggliatto LM; Hospital das Clinicas de Porto Alegre, Porto Alegre, Brazil.
  • Galvez KM; Hospital Pablo Tobón Uribe, Medellín, Colombia.
  • Gomez D; Hospital Universitario "Dr José E. González," Mexico City, Mexico.
  • Gomez A; Hemato Oncólogos SA, Valle, Colombia.
  • de Iracema D; CEPHO, Santo André, Brazil.
  • Farias D; Hospital das Clinicas da Universidade Federal de Goiás, Goiânia, Brazil.
  • Lopez L; Complejo Hospitalario Metropolitano Dr Annulfo Arias Madrid, Panama City, Panama.
  • Mantilla WA; Fundacion Cardioinfantil, Bogotá, Colombia.
  • Martínez D; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Mela MJ; FUNDALEU, Buenos Aires, Argentina.
  • Miguel CE; Fundacao Faculdade Regional de Medicina São José do Rio Preto, São José do Rio Preto, Brazil.
  • Ovilla R; Hospital Angeles Lomas, Huixquilucan, Mexico.
  • Palmer L; Complejo Médico de la PFA Churruca-Visca, Buenos Aires, Argentina.
  • Pavlovsky C; FUNDALEU, Buenos Aires, Argentina.
  • Ramos C; Hospital General de México, Mexico City, Mexico.
  • Remaggi G; FUNDALEU, Buenos Aires, Argentina.
  • Santucci R; Instituto de Ensino e Pesquisas São Lucas, São Paulo, Brazil.
  • Schusterschitz S; Hospital das Clinicas-Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Sossa CL; Fundacion Oftalmológica de Santander, Santander, Colombia.
  • Tuna-Aguilar E; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Vela J; Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Santos T; Janssen-Cilag Farmacêutica, São Paulo, Brazil.
  • de la Mora O; Hospital General de México, Mexico City, Mexico.
  • Machnicki G; Janssen-Cilag Farmacêutica, Buenos Aires, Argentina.
  • Fernandez M; Janssen-Cilag Farmacêutica, Buenos Aires, Argentina.
  • Barreyro P; Janssen-Cilag Farmacêutica, Buenos Aires, Argentina.
J Glob Oncol ; 5: 1-19, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31774711
ABSTRACT

PURPOSE:

Limited information is available on multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL) management in Latin America. The primary objective of the Hemato-Oncology Latin America (HOLA) study was to describe patient characteristics and treatment patterns of Latin American patients with MM, CLL, and NHL.

METHODS:

This study was a multicenter, retrospective, medical chart review of patients with MM, CLL, and NHL in Latin America identified between January 1, 2006, and December 31, 2015. Included were adults with at least 1 year of follow-up (except in cases of death within 1 year of diagnosis) treated at 30 oncology hospitals (Argentina, 5; Brazil, 9; Chile, 1; Colombia, 5; Mexico, 6; Panama/Guatemala, 4).

RESULTS:

Of 5,140 patients, 2,967 (57.7%) had NHL, 1,518 (29.5%) MM, and 655 (12.7%) CLL. Median follow-up was 2.2 years for MM, 3.0 years for CLL, and 2.2 years for NHL, and approximately 26% died during the study observation period. Most patients had at least one comorbidity at diagnosis. The most frequent induction regimen was thalidomide-based chemotherapy for MM and chlorambucil with or without prednisone for CLL. Most patients with NHL had diffuse large B-cell lymphoma (DLBCL; 49.1%) or follicular lymphoma (FL; 19.5%). The majority of patients with DLBCL or FL received rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.

CONCLUSION:

The HOLA study generated an unprecedented level of high-quality, real-world evidence on characteristics and treatment patterns of patients with hematologic malignancies. Regional disparities in patient characteristics may reflect differences in ethnoracial identity and level of access to care. These data provide needed real-world evidence to understand the disease landscape in Latin America and may be used to inform clinical and health policy decision making.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Leucemia Linfocítica Crônica de Células B / Mieloma Múltiplo Tipo de estudo: Estudo de rastreamento Limite: Adulto / Idoso / Humanos / Meia-Idade / Jovem adulto Idioma: Inglês Revista: J Glob Oncol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Leucemia Linfocítica Crônica de Células B / Mieloma Múltiplo Tipo de estudo: Estudo de rastreamento Limite: Adulto / Idoso / Humanos / Meia-Idade / Jovem adulto Idioma: Inglês Revista: J Glob Oncol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil
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