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Boron nitride nanotube@NiFe2O4: a highly efficient system for magnetohyperthermia therapy.
Cabral, Thaylice Cs; Ardisson, José D; de Miranda, Marcelo C; Gomes, Dawidson A; Fernandez-Outon, Luis E; Sousa, Edésia Mb; Ferreira, Tiago H.
Afiliação
  • Cabral TC; SENAN, Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Belo Horizonte, MG, Brasil.
  • Ardisson JD; SENAN, Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Belo Horizonte, MG, Brasil.
  • de Miranda MC; Departamento de Bioquímica e Imunologia, ICB, UFMG, Belo Horizonte, MG, Brasil.
  • Gomes DA; Departamento de Bioquímica e Imunologia, ICB, UFMG, Belo Horizonte, MG, Brasil.
  • Fernandez-Outon LE; SENAN, Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Belo Horizonte, MG, Brasil.
  • Sousa EM; Departamento de Física, ICEX, UFMG, Belo Horizonte, MG, Brasil.
  • Ferreira TH; SENAN, Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Belo Horizonte, MG, Brasil.
Nanomedicine (Lond) ; 14(23): 3075-3088, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31797726
ABSTRACT

Aim:

The field of nanotechnology promotes the development of innovative and more effective cancer therapies. This work is aimed to develop a hybrid system that combines the capacity of boron nitride nanotubes (BNNTs) to be internalized by tumor cells and the ability of nickel ferrite nanoparticles to efficiently release heat by induced AC magnetic heating. Materials &

methods:

The systems studied were characterized by using x-ray diffractometry, transmission electron microscopy, vibrating sample magnetometry and Mössbauer spectroscopy.

Results:

The ferrite nanoparticles attached to BNNT were able to achieve the required temperatures for magnetohyperthermia therapies. After cellular internalization, AC induced magnetic heating of BNNT@NiFe2O4 can kill almost 80% of Hela cells lineage in a single cycle.

Conclusion:

This system can be a highly efficient magnetohyperthermia agent in cancer therapy.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Nanomedicine (Lond) Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil