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Evaluation of the MR and pathology characteristics immediately following percutaneous MR-guided microwave ablation in a rabbit kidney VX2 tumor implantation model.
Int J Hyperthermia ; 36(1): 1197-1206, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31814458
ABSTRACT

PURPOSE:

This study aimed to evaluate the immediate efficacy of magnetic resonance (MR)-guided microwave ablation (MWA) in rabbit kidneys implanted with VX2 tumors.

MATERIALS AND METHODS:

MR-guided MWA was performed in eight VX2 tumor-bearing rabbits. MR images after ablation were obtained and analyzed. The differences between the tissue specimens and MR images obtained after ablation were compared.

RESULTS:

On the three-dimensional volumetric interpolated breath-hold T1-weighted (3D-VIBE-T1WI) sequence, a low signal intensity indicated the primary tumor at the center of the ablation area, which was surrounded by a peripheral high-signal area. The signal for the primary tumor in the fast spin-turbo spin-echo T2-weighted (FS-TSE-T2WI) sequence was lower than before, and the ablation zone showed a low signal that completely covered the primary tumor. There was no significant difference in volume among the low-signal areas of the primary tumor on FS-TSE-T2WI before MWA, the central low-signal area on 3D-VIBE-T1WI after MWA, and the tumor coagulation necrosis area on the tissue specimens (p > 0.05). No significant difference was found in the volume of ablation zones among the tissue specimens, the high-signal area around the lesion on the 3D-VIBE-T1WI sequence, and the low-signal area covering the lesion on the FS-TSE-T2WI sequence (p > 0.05).

CONCLUSION:

Magnetic resonance imaging (MRI) is an effective method for immediate efficacy evaluation of rabbit renal VX2 tumors after MWA and can serve as a valuable reference for the clinical assessment of post-ablative renal tumors.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Int J Hyperthermia Assunto da revista: Neoplasias / Terapêutica Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China