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Enantio- and Diastereoselective Synthesis of Chromeno[4,3-b]pyrrole Derivatives Bearing Tetrasubstituted Chirality Centers through Carbene Catalyzed Cascade Reactions.
Org Lett ; 22(1): 326-330, 2020 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-31833772
ABSTRACT
An NHC-catalyzed cascade cycloaddition reaction is developed for quick access to structurally sophisticated tetrahydrochromeno[4,3-b]pyrrole derivatives. A sterically congested tetrasubstituted chirality carbon center is formed during the cyclization process. All the α-, ß-, and carbonyl carbons of the enal substrates are functionalized in chemo- and stereoselective fashion. The multicyclic chromeno[4,3-b]pyrrole products are generally afforded in good yields with excellent enantio- and diastereoselectivities. Heavily substituted pyrroline derivatives can be afforded from the chiral products through simple protocols.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Org Lett Assunto da revista: Bioquímica Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China