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Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.
Int J Med Sci ; 16(12): 1557-1563, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31839743
ABSTRACT
E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 in vivo. We examined phenotypic abnormalities, by deletion of the E2f3 gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The E2f3+/ - mouse embryo developed normally without fatal disorder. However, they exhibited reduced body weight, growth retardation, skeletal imperfection, and poor grip strength ability. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Desenvolvimento Ósseo / Músculo Esquelético / Desenvolvimento Embrionário / Fator de Transcrição E2F3 Limite: Animais / Humanos Idioma: Inglês Revista: Int J Med Sci Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo