[Association of polyunsaturated fatty acids treatment with coronary mortality. A meta-analysis].
Kardiologiia
; 59(11S): 63-68, 2019 Oct 30.
Article
em Ru
| MEDLINE
| ID: mdl-31884942
ABSTRACT
AIM:
A meta-analysis was undertaken to sum up data on long-chain polyunsaturated fatty acids treatment and coronary deaths.METHODS:
Only studies with no less than 500 participants and length of follow-up no less than one year were included. Total number of studies was 13 with 127455 participants.RESULTS:
Fixed factor (Peto) model demonstrated significant decrease in cardiac deaths in polyunsaturated fatty acids -treated group. (OR=0,89, 95%CI 0,83-0,95, Ñ=0,001). Random factor model confidence interval also does not included one (OR=0,88, 95%CI 0,80-0,97, p=0.008). Subgroup analysis of studies that used therapy with 460 mg eicosapentaenoic acid and 380 docosahexaenoic acid per day demonstrated significant reduction in cardiac deaths (OR=0,84, 95%CI 0,77-0,92) in both fixed factor and random factor models.CONCLUSION:
Correspondingly supplementation with polyunsaturated fatty acids associated with lower coronary mortality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Insaturados
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
Ru
Revista:
Kardiologiia
Ano de publicação:
2019
Tipo de documento:
Article