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Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.
Anticancer Res ; 40(1): 27-34, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31892550


Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking.


A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.


rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer.


IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Afro-Americanos / Fumar / Regiões Promotoras Genéticas / Interleucina-10 / Polimorfismo de Nucleotídeo Único Tipo de estudo: Estudo de casos e controles Aspecto clínico: Etiologia / Prognóstico Limite: Idoso / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Anticancer Res Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos