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Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.
Anticancer Res ; 40(1): 27-34, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31892550
ABSTRACT

BACKGROUND/AIM:

Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking.

MATERIALS AND METHODS:

A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

RESULTS:

rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer.

CONCLUSION:

IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Afro-Americanos / Fumar / Regiões Promotoras Genéticas / Interleucina-10 / Polimorfismo de Nucleotídeo Único Tipo de estudo: Estudo de casos e controles Aspecto clínico: Etiologia / Prognóstico Limite: Idoso / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Anticancer Res Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos