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Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines.
Anticancer Res ; 40(1): 557-564, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31892612
ABSTRACT

BACKGROUND/AIM:

Ultraviolet radiation (UVR) causes solar lentigines (SL) and skin cancer (SC) in humans. The association between measured lifetime UVR dose and SC has not been investigated. This study investigated this relation through their common relationship to SL.

MATERIALS AND METHODS:

First we investigated the association between lifetime UVR dose and SL for 16,897 days in 38 healthy participants, and secondly, the relation between SL and SC was investigated in 2,898 participants, including 149 with SC. By combining both studies, SC risk related to lifetime UVR dose and skin phototype was estimated.

RESULTS:

A positive association was found between SL and lifetime UVR dose (p=0.060). Skin phototype (p=0.001) and SL (p<0.001) were associated with SC. Combined SC risk increased 1.23 by doubling the average lifetime UVR dose and was 34.9 times higher for those with very fair skin compared to dark Mediterranean skin.

CONCLUSION:

The estimate of SC risk shows that skin phototype is of greater relative importance than lifetime UVR dose.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Raios Ultravioleta / Lentigo Aspecto clínico: Etiologia Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Anticancer Res Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Dinamarca