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Clinical and Statistical Considerations when Assessing Oxygen Levels in Tumors: Illustrative Results from Clinical EPR Oximetry Studies.
Adv Exp Med Biol ; 1232: 155-168, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893406
ABSTRACT
The success of treatment for malignancies, especially those undergoing radiation therapy or chemotherapy, has long been recognized to depend on the degree of hypoxia in the tumor. In addition to the prognostic value of knowing the tumor's initial level of hypoxia, assessing the tumor oxygenation during standard therapy or oxygen-related treatments (such as breathing oxygen-enriched gas mixtures or taking drugs that can increase oxygen supply to tissues) can provide valuable data to improve the efficacy of treatments. A series of early clinical studies of tumors in humans are ongoing at Dartmouth and Emory using electron paramagnetic resonance (EPR) oximetry to assess tumor oxygenation, initially and over time during either natural disease progression or treatment. This approach has the potential for reaching the long-sought goal of enhancing the effectiveness of cancer therapy. In order to effectively reach this goal, we consider the validity of the practical and statistical assumptions when interpreting the measurements made in vivo for patients undergoing treatment for cancer.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Oxigênio / Oximetria / Hipóxia Tumoral / Neoplasias Tipo de estudo: Guia de prática clínica Aspecto clínico: Prognóstico Limite: Humanos Idioma: Inglês Revista: Adv Exp Med Biol Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos