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Functional connectivity of the supplementary motor network is associated with Fried's modified frailty score in the elderly.
Artigo em Inglês | MEDLINE | ID: mdl-31900470
ABSTRACT
Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, i. e. (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state fMRI, motor-cognitive testing and assessment of Fried's modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N=60) showed higher connectivity in the SMA network compared to frail (N=13) and pre-frail (N=70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the elderly. The SMA may serve as a potential treatment target in frailty.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Aspecto clínico: Etiologia Idioma: Inglês Assunto da revista: Geriatria Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Alemanha