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Recent advances in functional mesoporous silica-based nanoplatforms for combinational photo-chemotherapy of cancer.
Biomaterials ; 232: 119738, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31901695
ABSTRACT
In recent years, research trend has gradually removed from a concentration on monotherapy to combination therapy for fighting cancer. Combination photo-chemotherapy, including photodynamic-chemotherapy, photothermal-chemotherapy, as well as photodynamic-photothermal-chemotherapy, has demonstrated the priorities to elevate cancer therapeutic efficacies and diminish undesired side effects through different mechanisms in cancer treatment. In this review, we summarize the most recent progress in designing mesoporous silica-based nanoplatforms for combination delivery of multiple therapeutic agents, and discuss the treatment outcome in cancer by combining photodynamic therapy (PDT) and/or photothermal therapy (PTT) with chemotherapy. Furthermore, we highlight the drawbacks and challenges of employing mesoporous silica-based combinational formulations for effective cancer photo-chemotherapy, which might provide new guidelines for development of photo-chemo combination cancer treatments.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Biomaterials Ano de publicação: 2020 Tipo de documento: Artigo