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Eculizumab for Severe Thrombotic Microangiopathy Secondary to Surgical Invasive Stress and Bleeding.
Fujita, Yoko; Terashita, Maho; Yazawa, Masahiko; Yamasaki, Yukitaka; Imamura, Tomonori; Kibayashi, Junichiro; Sawai, Toshihiro; Hidaka, Yoshihiko; Ohtani, Katsuki; Inoue, Norimitsu; Shibagaki, Yugo.
Afiliação
  • Fujita Y; Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.
  • Terashita M; Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.
  • Yazawa M; Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.
  • Yamasaki Y; Department of Infectious Disease, St. Marianna University School of Medicine, Japan.
  • Imamura T; Department of Emergency and Critical Care Medicine, Tokyo Metropolitan Police Hospital, Japan.
  • Kibayashi J; Department of Obstetrics and Gynecology, Yokohama General Hospital, Japan.
  • Sawai T; Department of Pediatrics, Shiga University of Medical Science, Japan.
  • Hidaka Y; Department of Molecular Genetics, Wakayama Medical University, Japan.
  • Ohtani K; The Japanese Association for Complement Research, Japan.
  • Inoue N; The Japanese Association for Complement Research, Japan.
  • Shibagaki Y; Department of Food and Health Sciences, Rakuno Gakuen University, Japan.
Intern Med ; 59(1): 93-99, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31902910
ABSTRACT
Atypical hemolytic uremic syndrome (aHUS) is an extremely rare condition caused by an excessive activation of the complement pathway based on genetic or acquired dysfunctions in complement regulation, leading to thrombotic microangiopathy (TMA). A complement-amplifying condition (CAC) can trigger aHUS occurrence along with complement abnormality. We herein report a case of severe TMA after laparoscopic myomectomy in a healthy woman. This case was eventually diagnosed as complement-mediated TMA secondary to surgical invasive stress as a CAC, with no definitive diagnosis of aHUS despite a genetic test. The patient fully recovered after several eculizumab administrations.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Laparoscopia / Hemorragia Pós-Operatória / Microangiopatias Trombóticas / Anticorpos Monoclonais Humanizados / Miomectomia Uterina Tipo de estudo: Relato de casos / Estudo diagnóstico / Estudo de etiologia Limite: Adulto / Feminino / Humanos Idioma: Inglês Revista: Intern Med Assunto da revista: Medicina Interna Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Japão

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Laparoscopia / Hemorragia Pós-Operatória / Microangiopatias Trombóticas / Anticorpos Monoclonais Humanizados / Miomectomia Uterina Tipo de estudo: Relato de casos / Estudo diagnóstico / Estudo de etiologia Limite: Adulto / Feminino / Humanos Idioma: Inglês Revista: Intern Med Assunto da revista: Medicina Interna Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Japão
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