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Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers.
Sinxadi, Phumla; Donini, Cristina; Johnstone, Hilary; Langdon, Grant; Wiesner, Lubbe; Allen, Elizabeth; Duparc, Stephan; Chalon, Stephan; McCarthy, James S; Lorch, Ulrike; Chibale, Kelly; Möhrle, Jörg; Barnes, Karen I.
Afiliação
  • Sinxadi P; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Donini C; UCT MRC Collaborating Centre for Optimising Antimalarial Therapy, University of Cape Town, Cape Town, South Africa.
  • Johnstone H; Medicines for Malaria Venture, Geneva, Switzerland.
  • Langdon G; HJ-Clinical Trial Consultancy, George, South Africa.
  • Wiesner L; PTx Solutions Limited, London, United Kingdom.
  • Allen E; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Duparc S; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Chalon S; UCT MRC Collaborating Centre for Optimising Antimalarial Therapy, University of Cape Town, Cape Town, South Africa.
  • McCarthy JS; Medicines for Malaria Venture, Geneva, Switzerland.
  • Lorch U; Medicines for Malaria Venture, Geneva, Switzerland.
  • Chibale K; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Möhrle J; Richmond Pharmacology, London, United Kingdom.
  • Barnes KI; Drug Discovery and Development Centre (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Cape Town, South Africa.
Antimicrob Agents Chemother ; 64(4)2020 03 24.
Article em En | MEDLINE | ID: mdl-31932368
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Sulfonas / Malária Falciparum / Aminopiridinas / Antimaláricos Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: África do Sul País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Sulfonas / Malária Falciparum / Aminopiridinas / Antimaláricos Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: África do Sul País de publicação: Estados Unidos