Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction: Hope for Better Aging?

Rosas, Paola C; Warren, Chad M; Creed, Heidi A; Trzeciakowski, Jerome P; Solaro, R John; Tong, Carl W

Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction: Hope for Better Aging?

Rosas, Paola C; Warren, Chad M; Creed, Heidi A; Trzeciakowski, Jerome P; Solaro, R John; Tong, Carl W.

Afiliação

Rosas PC; Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Warren CM; Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Creed HA; Department of Medical Physiology, Texas A and M University Health Science Center, College of Medicine, College Station, Texas.
Trzeciakowski JP; Department of Medical Physiology, Texas A and M University Health Science Center, College of Medicine, College Station, Texas.
Solaro RJ; Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Tong CW; Department of Medical Physiology, Texas A and M University Health Science Center, College of Medicine, College Station, Texas.

JACC Basic Transl Sci ; 4(7): 817-830, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31998850

Palavras-chave

3SA, mutated 3 serines to 3 alanines to mimic hypophosphorylated cardiac myosin binding protein-C (S273A, S282A, and S302A); 3SD, mutated 3 serines to 3 aspartic acids to mimic phosphorylated cMyBP-C (S273D, S282D, and S302D); ANOVA, analysis of variance; EF, ejection fraction; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HOP, hydroxyproline; LV, left ventricular; aging; cMyBP-C, cardiac myosin binding protein-C; cTnI, cardiac troponin I; cardiac myosin binding protein-C; dyastolic dysfunction; heart failure; phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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