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Clinical and biological factors associated with early Epstein-Barr Virus infection in HIV-Exposed Uninfected Infants in Eastern Uganda.
Montoya-Ferrer, Ana; Sanosyan, Armen; Fayd'herbe De Maudave, Alexis; Pisoni, Amandine; Bollore, Karine; Molès, Jean-Pierre; Peries, Marianne; Tylleskar, Thorkild; Tumwine, James K; Ndeezi, Grace; Gorgolas, Miguel; Nagot, Nicolas; Van De Perre, Philippe; Tuaillon, Edouard.
Afiliação
  • Montoya-Ferrer A; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Sanosyan A; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Fayd'herbe De Maudave A; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Pisoni A; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Bollore K; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Molès JP; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Peries M; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Tylleskar T; Centre for International Health, University of Bergen, Bergen, Norway.
  • Tumwine JK; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Ndeezi G; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Gorgolas M; Department of Infectious Diseases, Hospital Fundación Jiménez-Díaz, University Autonoma, Madrid, Spain.
  • Nagot N; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Van De Perre P; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
  • Tuaillon E; Pathogenesis and Control of Chronic Infections, INSERM, Etablissement français du Sang, University of Montpellier, CHU Montpellier, Montpellier, France.
Clin Infect Dis ; 2020 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-32067040
ABSTRACT

BACKGROUND:

Immune control of Epstein-Barr virus (EBV) infection is impaired in HIV-infected individuals. We explored maternal factors associated with EBV acquisition in HIV-exposed uninfected (HEU) infants and the relationship between EBV infection and serious adverse events (SAE) during the first year of life.

METHODS:

Two hundred and one HEU infants from Uganda enrolled in the ANRS12174 trial were tested for anti-viral capsid antigen (VCA) antibodies at week 50 of life. The date of infection was estimated by testing of EBV DNA at weeks 1, 6, 14, 26, 38 and 50 postpartum on dried blood spot (DBS).

RESULTS:

Eighty-seven (43%) infants were tested positive for anti-VCA IgG at week 50. Among the 59 infants positive for EBV DNA, 25% were infected within the first 26 weeks. Almost half of them (12%) were infected before week 14. Shedding of EBV in breast milk was associated with EBV DNA in maternal plasma (P=.009), HIV RNA detection (P=.039), lower CD4 count (P=.001) and was correlated with plasma EBV DNA levels (P=.002). EBV infant infection at week 50 was associated with shedding of EBV in breast milk (P=.009) and young maternal age (P=.029). Occurrence of a clinical SAE, including malaria and pneumonia, was associated with higher levels of EBV DNA in infants (P=.010).

CONCLUSIONS:

By assessing EBV infection in HEU infants we observed that infection during the first year of life is determined by HIV and EBV maternal factors and that EBV DNA levels was higher among infants with clinical SAE.
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Malária Base de dados: MEDLINE Tipo de estudo: Fatores de risco Idioma: Inglês Assunto da revista: Doenças Transmissíveis Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: França

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Malária Base de dados: MEDLINE Tipo de estudo: Fatores de risco Idioma: Inglês Assunto da revista: Doenças Transmissíveis Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: França