Metabolomic change and pathway profiling reveal enhanced ansamitocin P-3 production in Actinosynnema pretiosum with low organic nitrogen availability in culture medium.

Liu, Ting; Yang, Linbing; Chen, Jun; Hu, Fengxian; Wei, Liu-Jing; Hua, Qiang

Liu, Ting; Yang, Linbing; Chen, Jun; Hu, Fengxian; Wei, Liu-Jing; Hua, Qiang.

Afiliação

Liu T; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Yang L; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Chen J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Hu F; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Wei LJ; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Hua Q; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. qhua@ecust.edu.cn.

Appl Microbiol Biotechnol ; 104(8): 3555-3568, 2020 Apr.

Article em En | MEDLINE | ID: mdl-32114676

Assuntos

Actinobacteria/crescimento & desenvolvimento; Actinobacteria/metabolismo; Meios de Cultura/química; Maitansina/análogos & derivados; Redes e Vias Metabólicas; Nitrogênio/metabolismo; Actinobacteria/genética; Vias Biossintéticas/genética; Carbono/metabolismo; Fermentação; Perfilação da Expressão Gênica; Maitansina/biossíntese; Engenharia Metabólica/métodos; Metabolômica

Palavras-chave

Actinosynnema pretiosum; Ansamitocins; Metabolomics; Organic nitrogen availability; Pathway profiling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinobacteria / Meios de Cultura / Redes e Vias Metabólicas / Maitansina / Nitrogênio Tipo de estudo: Prognostic_studies Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Alemanha

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