Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B.

Shi, Ke; Demir, Özlem; Carpenter, Michael A; Banerjee, Surajit; Harki, Daniel A; Amaro, Rommie E; Harris, Reuben S; Aihara, Hideki

Shi, Ke; Demir, Özlem; Carpenter, Michael A; Banerjee, Surajit; Harki, Daniel A; Amaro, Rommie E; Harris, Reuben S; Aihara, Hideki.

Afiliação

Shi K; Department of Biochemistry, Molecular Biology and Biophysics University of Minnesota Minneapolis MN USA.
Demir Ö; Masonic Cancer Center University of Minnesota Minneapolis MN USA.
Carpenter MA; Institute for Molecular Virology University of Minnesota Minneapolis MN USA.
Banerjee S; Department of Chemistry and Biochemistry University of California, San Diego La Jolla CA USA.
Harki DA; Department of Biochemistry, Molecular Biology and Biophysics University of Minnesota Minneapolis MN USA.
Amaro RE; Masonic Cancer Center University of Minnesota Minneapolis MN USA.
Harris RS; Institute for Molecular Virology University of Minnesota Minneapolis MN USA.
Aihara H; Center for Genome Engineering University of Minnesota Minneapolis MN USA.

FASEB Bioadv ; 2(1): 49-58, 2020 Jan.

Article em En | MEDLINE | ID: mdl-32123856

Palavras-chave

APOBEC3B; DNA mutation; active site plasticity; cytosine deaminase; enzymes; molecular dynamics simulations; protein structure; small molecule; xray crystallography; zinc ion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: FASEB Bioadv Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

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