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What do Cochrane systematic reviews say about interventions for age-related macular degeneration?
Sao Paulo Med J ; 137(6): 530-542, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32159640


Age-related macular degeneration (AMD) is the third largest cause of blindness worldwide, accounting for 8.7% of all cases. A considerable number of preventive or therapeutic interventions have been used for AMD.


This study presents a critical view of the interventions that have been assessed through Cochrane systematic reviews. DESIGN AND


Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP).


Review of Cochrane systematic reviews about interventions for AMD.


The 18 systematic reviews included assessed the effects of surgical techniques, laser/photo/radiotherapy, intravitreal injections, systemic drugs and phytotherapy/vitamins/supplements.


The Cochrane systematic reviews found evidence that use of bevacizumab, ranibizumab, pegaptanib, laser photocoagulation, photodynamic therapy and multivitamin compounds may present some benefits for treating AMD. There was insufficient evidence for supporting the use of macular translocation, submacular surgery, steroid implantation, radiotherapy, intravitreal aflibercept, interferon alfa, statins or omega-3 fatty acids for treating AMD; or the use of multivitamin antioxidant vitamins or mineral supplementation for preventing AMD. Future randomized controlled trials are imperative to reduce the uncertainty in several clinical questions regarding AMD.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Medicina Baseada em Evidências / Degeneração Macular Tipo de estudo: Ensaio clínico controlado Aspecto clínico: Terapia Limite: Humanos Idioma: Inglês Revista: Sao Paulo Med J Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil