Intraoperative partial irradiation for highly selected patients with breast cancer: Results of the INTRAOBS prospective study.
Cancer Radiother
; 24(2): 114-119, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-32171675
ABSTRACT
PURPOSE:
To evaluate our long-term experience on one-day breast intraoperative radiotherapy (IORT) given as sole radiation treatment to selected patients with breast cancer. METHODS AND MATERIALS Inclusion criteria of INTRAOBS study (prospective observational study) were ER+ T1N0 unifocal ductal carcinoma; absence of lymphovascular invasion or of extensive intraductal component (Scarff-Bloom-Richardson grade III and HER2+++ excluded). Two different linacs were used (20Gy/1 fraction) one dedicated electron linac (RESULTS:
Of the present pre-planned analysis for the first 200 patients (median age 68 years; range, 59-87 years) who received IORT between January 2010 and October 2014 (median follow-up of 53.4 months). A total of 193 patients were still alive. The local recurrence rate was 2.5% (n=5). The 1- and 5-year local RFS rates were 100% and 95.2%, respectively. At 12 months post-surgery, satisfaction about IORT was excellent for 86.9% of patients. Cosmetic results were considered by patients and physicians as good or very good in 89.4% and 97.3% of cases, respectively.CONCLUSIONS:
IORT for selected patients with breast cancer shows low recurrence rates, good cosmetic outcomes and excellent satisfaction.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Segunda Neoplasia Primária
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Carcinoma Ductal de Mama
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Seleção de Pacientes
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Cancer Radiother
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
França