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Cationic Biphotonic Lanthanide Luminescent Bioprobes Based on Functionalized Cross-Bridged Cyclam Macrocycles.
Mendy, Jonathan; Thy Bui, Anh; Roux, Amandine; Mulatier, Jean-Christophe; Curton, Damien; Duperray, Alain; Grichine, Alexei; Guyot, Yannick; Brasselet, Sophie; Riobé, François; Andraud, Chantal; Le Guennic, Boris; Patinec, Véronique; Tripier, Pr Raphael; Beyler, Maryline; Maury, Olivier.
Afiliação
  • Mendy J; Univ Brest, UMR CNRS-UBO 6521 CEMCA, IBSAM, UFR des Sciences et Techniques, 6 Avenue Victor le Gorgeu, C.S. 93837, F-29238, Brest, Cedex 3, France.
  • Thy Bui A; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
  • Roux A; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
  • Mulatier JC; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
  • Curton D; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
  • Duperray A; INSERM, U1209, Université Grenoble Alpes, IAB, F-38000, Grenoble, France.
  • Grichine A; INSERM, U1209, Université Grenoble Alpes, IAB, F-38000, Grenoble, France.
  • Guyot Y; Univ Lyon, Institut Lumière Matière, UMR 5306 CNRS -, Université Claude Bernard Lyon 1, 10 rue Ada Byron, F-69622, Villeurbanne Cedex, France.
  • Brasselet S; Univ Aix Marseille, CNRS, Centrale Marseille, Institut Fresnel, UMR 7249, F-13013, Marseille, France.
  • Riobé F; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
  • Andraud C; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
  • Le Guennic B; Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000, Rennes, France.
  • Patinec V; Univ Brest, UMR CNRS-UBO 6521 CEMCA, IBSAM, UFR des Sciences et Techniques, 6 Avenue Victor le Gorgeu, C.S. 93837, F-29238, Brest, Cedex 3, France.
  • Tripier PR; Univ Brest, UMR CNRS-UBO 6521 CEMCA, IBSAM, UFR des Sciences et Techniques, 6 Avenue Victor le Gorgeu, C.S. 93837, F-29238, Brest, Cedex 3, France.
  • Beyler M; Univ Brest, UMR CNRS-UBO 6521 CEMCA, IBSAM, UFR des Sciences et Techniques, 6 Avenue Victor le Gorgeu, C.S. 93837, F-29238, Brest, Cedex 3, France.
  • Maury O; Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342, Lyon, France.
Chemphyschem ; 21(10): 1036-1043, 2020 05 18.
Artigo em Inglês | MEDLINE | ID: mdl-32176399
ABSTRACT
Cationic lanthanide complexes are generally able to spontaneously internalize into living cells. Following our previous works based on a diMe-cyclen framework, a second generation of cationic water-soluble lanthanide complexes based on a constrained cross-bridged cyclam macrocycle functionalized with donor-π-conjugated picolinate antennas was prepared with europium(III) and ytterbium(III). Their spectroscopic properties were thoroughly investigated in various solvents and rationalized with the help of DFT calculations. A significant improvement was observed in the case of the Eu3+ complex, while the Yb3+ analogue conserved photophysical properties in aqueous solvent. Two-photon (2P) microscopy imaging experiments on living T24 human cancer cells confirmed the spontaneous internalization of the probes and images with good signal-to-noise ratio were obtained in the classic NIR-to-visible configuration with the Eu3+ luminescent bioprobe and in the NIR-to-NIR with the Yb3+ one.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Chemphyschem Assunto da revista: Biofísica / Química Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: França