Efficient optimization of high-dose formulation of novel lyophilizates for dry powder inhalation by the combination of response surface methodology and time-of-flight measurement.

Ohori, Ryo; Kiuchi, Sakurako; Sugiyama, Shintaro; Miyamoto, Kahori; Akita, Tomomi; Yamashita, Chikamasa

Ohori, Ryo; Kiuchi, Sakurako; Sugiyama, Shintaro; Miyamoto, Kahori; Akita, Tomomi; Yamashita, Chikamasa.

Afiliação

Ohori R; Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Kiuchi S; Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Sugiyama S; Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Miyamoto K; Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Akita T; Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Yamashita C; Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address: chikamasa_yamashita@rs.tus.ac.jp.

Int J Pharm ; 581: 119255, 2020 May 15.

Article em En | MEDLINE | ID: mdl-32217154

Assuntos

Produtos Biológicos/administração & dosagem; Composição de Medicamentos/métodos; Inaladores de Pó Seco; Excipientes/química; Administração por Inalação; Aerossóis; Química Farmacêutica; Relação Dose-Resposta a Droga; Liofilização; Leucina/química; Muramidase/administração & dosagem; Tamanho da Partícula; Fenilalanina/química; Pós

Palavras-chave

DPI; Dry powder inhalation; Freeze drying; Inhalation; Lyophilization; Pulmonary administration; Response surface

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Composição de Medicamentos / Excipientes / Inaladores de Pó Seco Idioma: En Revista: Int J Pharm Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google