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Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer.
Gupta, Samir; Bharti, Balambal; Ahnen, Dennis J; Buchanan, Daniel D; Cheng, Iona C; Cotterchio, Michelle; Figueiredo, Jane C; Gallinger, Steven J; Haile, Robert W; Jenkins, Mark A; Lindor, Noralane M; Macrae, Finlay A; Le Marchand, Loïc; Newcomb, Polly A; Thibodeau, Stephen N; Win, Aung Ko; Martinez, Maria Elena.
Afiliação
  • Gupta S; Section of Gastroenterology, San Diego Veterans Affairs Healthcare System, San Diego, California.
  • Bharti B; Department of Medicine, University of California at San Diego, La Jolla, California.
  • Ahnen DJ; Moores Cancer Center, University of California at San Diego, La Jolla, California.
  • Buchanan DD; Department of Medicine, University of California at San Diego, La Jolla, California.
  • Cheng IC; Moores Cancer Center, University of California at San Diego, La Jolla, California.
  • Cotterchio M; Department of Medicine, Division of Gastroenterology & Hepatology, University of Colorado Anschutz Medical Center, Aurora, Colorado.
  • Figueiredo JC; Gastroenterology of the Rockies, Boulder, Colorado.
  • Gallinger SJ; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.
  • Haile RW; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
  • Jenkins MA; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
  • Lindor NM; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California.
  • Macrae FA; Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
  • Le Marchand L; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Newcomb PA; Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Thibodeau SN; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Win AK; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
  • Martinez ME; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Cancer ; 126(13): 3013-3020, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32307706
ABSTRACT

BACKGROUND:

Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early-onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history-based guidelines for identifying individuals with EOCRC.

METHODS:

The authors conducted a population-based, case-control study of individuals aged 40 to 49 years with (2473 individuals) and without (772 individuals) incident CRC in the Colon Cancer Family Registry from 1998 through 2007. They estimated the sensitivity and specificity of family history-based criteria jointly recommended by the American Cancer Society, the US Multi-Society Task Force on CRC, and the American College of Radiology in 2008 for early screening, and the age at which each participant could have been recommended screening initiation if these criteria had been applied.

RESULTS:

Family history-based early screening criteria were met by approximately 25% of cases (614 of 2473 cases) and 10% of controls (74 of 772 controls), with a sensitivity of 25% and a specificity of 90% for identifying EOCRC cases aged 40 to 49 years. Among 614 individuals meeting early screening criteria, 98.4% could have been recommended screening initiation at an age younger than the observed age of diagnosis.

CONCLUSIONS:

Of CRC cases aged 40 to 49 years, 1 in 4 met family history-based early screening criteria, and nearly all cases who met these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per family history-based guidelines. Additional strategies are needed to improve the detection and prevention of EOCRC for individuals not meeting family history criteria for early screening.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo diagnóstico / Guia de prática clínica / Estudo observacional / Estudo prognóstico / Estudo de rastreamento Idioma: Inglês Revista: Cancer Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo diagnóstico / Guia de prática clínica / Estudo observacional / Estudo prognóstico / Estudo de rastreamento Idioma: Inglês Revista: Cancer Ano de publicação: 2020 Tipo de documento: Artigo