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In vitro activity of TNP-2092 against periprosthetic joint infection-associated staphylococci.
Fisher, Cody R; Schmidt-Malan, Suzannah M; Ma, Zhenkun; Yuan, Ying; He, Shijie; Patel, Robin.
Afiliação
  • Fisher CR; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  • Schmidt-Malan SM; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  • Ma Z; TenNor Therapeutics Limited, Suzhou, China.
  • Yuan Y; TenNor Therapeutics Limited, Suzhou, China.
  • He S; TenNor Therapeutics Limited, Suzhou, China.
  • Patel R; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN. Electronic address: patel.robin@mayo.edu.
Diagn Microbiol Infect Dis ; 97(3): 115040, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32354459
ABSTRACT
Staphylococci are the most common causes of periprosthetic joint infection (PJI). TNP-2092 is an investigational hybrid drug composed of rifamycin and quinolizinone pharmacophores conjugated via a covalent linker. We determined minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm bactericidal concentration (MBBC) values of TNP-2092 against 80 PJI-associated Staphylococcus aureus and Staphylococcus epidermidis isolates compared to ciprofloxacin and rifampin alone and in combination, alongside daptomycin and vancomycin. TNP-2092 exhibited the following activity against S. aureus MIC50/MIC90, ≤0.0075/0.015 µg/mL; MBC50/MBC90, 0.5/4 µg/mL; and MBBC50/MBBC90, 0.5/2 µg/mL, and the following activity against S. epidermidis MIC50/MIC90, ≤0.0075/0.015 µg/mL; MBC50/MBC90, 0.015/0.125 µg/mL; and MBBC50/MBBC90, 0.06/0.25 µg/mL. TNP-2092 MIC, MBC, and MBBC values were >8 µg/mL for 1 isolate, while MIC values were ≤0.25 µg/mL and MBC and MBBC values were ≤4 µg/mL for all other isolates. Results of this study show that TNP-2092 has promising in vitro activity against PJI-associated staphylococci.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Diagn Microbiol Infect Dis Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Mongólia

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Diagn Microbiol Infect Dis Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Mongólia
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