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Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study.
Nery, Fabiano G; Wilson, Anna R; Schneider, Marguerite R; Strawn, Jeffrey R; Patino, Luis R; McNamara, Robert K; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P.
Afiliação
  • Nery FG; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Wilson AR; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Schneider MR; Harvard Longwood Psychiatry Residency Training Program, Boston, MA, USA.
  • Strawn JR; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Patino LR; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • McNamara RK; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Adler CM; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Strakowski SM; Department of Psychiatry, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
  • DelBello MP; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Braz J Psychiatry ; 42(5): 481-488, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32401870
ABSTRACT

OBJECTIVES:

To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder.

METHODS:

Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion).

RESULTS:

Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion.

CONCLUSIONS:

Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Transtorno Depressivo Maior Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Criança / Humanos / Jovem adulto Idioma: Inglês Revista: Braz J Psychiatry Assunto da revista: Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Transtorno Depressivo Maior Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Criança / Humanos / Jovem adulto Idioma: Inglês Revista: Braz J Psychiatry Assunto da revista: Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos