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Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.
Morianos, Ioannis; Trochoutsou, Aikaterini I; Papadopoulou, Gina; Semitekolou, Maria; Banos, Aggelos; Konstantopoulos, Dimitris; Manousopoulou, Antigoni; Kapasa, Maria; Wei, Ping; Lomenick, Brett; Belaidi, Elise; Kalamatas, Themis; Karageorgiou, Klinta; Doskas, Triantafyllos; Sallusto, Federica; Pan, Fan; Garbis, Spiros D; Quintana, Francisco J; Xanthou, Georgina.
Afiliação
  • Morianos I; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Trochoutsou AI; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Papadopoulou G; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Semitekolou M; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Banos A; Division of Immunobiology, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Konstantopoulos D; Department of Molecular Biology and Genetics, Biomedical Sciences Research Center "Alexander Fleming", 16672 Athens, Greece.
  • Manousopoulou A; Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
  • Kapasa M; Molecular Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Wei P; Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Lomenick B; Proteome Exploration Laboratory, Beckman Institute, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
  • Belaidi E; Laboratoire HP2, University Grenoble Alpes, F-38042 Grenoble, France.
  • Kalamatas T; INSERM, U1042 Grenoble, France.
  • Karageorgiou K; Department of Neurology, "G. Gennimatas" General State Hospital of Athens, 115 27 Athens, Greece.
  • Doskas T; Department of Neurology, Athens Medical Center, 151 25 Athens, Greece.
  • Sallusto F; Department of Neurology, Athens Naval Hospital, 115 21 Athens, Greece.
  • Pan F; Institute of Microbiology, Eidgenössiche Technische Hochschule, 8093 Zürich, Switzerland.
  • Garbis SD; Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Quintana FJ; Proteome Exploration Laboratory, Beckman Institute, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
  • Xanthou G; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Proc Natl Acad Sci U S A ; 117(22): 12269-12280, 2020 06 02.
Article em En | MEDLINE | ID: mdl-32409602
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apirase / Antígenos CD / 5'-Nucleotidase / Ativinas / Encefalomielite Autoimune Experimental / Subunidade alfa do Fator 1 Induzível por Hipóxia / Células Th17 / Inflamação / Esclerose Múltipla Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Grécia País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apirase / Antígenos CD / 5'-Nucleotidase / Ativinas / Encefalomielite Autoimune Experimental / Subunidade alfa do Fator 1 Induzível por Hipóxia / Células Th17 / Inflamação / Esclerose Múltipla Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Grécia País de publicação: Estados Unidos