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Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations.
Sonmez, A Irem; Almorsy, Ammar; Ramsey, Laura B; Strawn, Jeffrey R; Croarkin, Paul E.
Afiliação
  • Sonmez AI; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.
  • Almorsy A; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.
  • Ramsey LB; Division of Research in Patient Services and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Strawn JR; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio.
  • Croarkin PE; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.
Depress Anxiety ; 37(8): 747-759, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32419335
ABSTRACT

BACKGROUND:

Pediatric anxiety disorders such as generalized anxiety disorder (GAD) are common, impairing, and often undertreated. Moreover, many youth do not respond to standard, evidence-based psychosocial or psychopharmacologic treatment. An increased understanding of the gamma-aminobutyric acid (GABA) and glutamate neurotransmitter systems has created opportunities for novel intervention development for pediatric GAD.

METHODS:

This narrative review examines potential candidates for pediatric GAD eszopiclone, riluzole, eglumegad (LY354740), pimavanserin, agomelatine.

RESULTS:

The pharmacology, preclinical data, clinical trial findings and known side effects of eszopiclone, riluzole, eglumegad (LY354740), pimavanserin, agomelatine, are reviewed, particularly with regard to their potential therapeutic relevance to pediatric GAD.

CONCLUSION:

Notwithstanding numerous challenges, some of these agents represent potential candidate drugs for pediatric GAD. Further treatment development studies of agomelatine, eszopiclone, pimavanserin and riluzole for pediatric GAD also have the prospect of informing the understanding of GABAergic and glutamatergic function across development.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Depress Anxiety Assunto da revista: Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Depress Anxiety Assunto da revista: Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo
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