Your browser doesn't support javascript.
loading
Association of Multiple Aggregated Yellow-White Globules With Nonpigmented Basal Cell Carcinoma.
Navarrete-Dechent, Cristian; Liopyris, Konstantinos; Rishpon, Ayelet; Marghoob, Nadeem G; Cordova, Miguel; Dusza, Stephen W; Sahu, Aditi; Kose, Kivanc; Oliviero, Margaret; Rabinovitz, Harold; Busam, Klaus J; Marchetti, Michael A; Chen, Chih-Chan J; Marghoob, Ashfaq A.
Afiliação
  • Navarrete-Dechent C; Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Liopyris K; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Rishpon A; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Marghoob NG; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Cordova M; Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Dusza SW; New York Institute of Technology College of Osteopathic Medicine, New York.
  • Sahu A; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Kose K; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Oliviero M; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Rabinovitz H; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Busam KJ; Skin and Cancer Associates, Plantation, Florida.
  • Marchetti MA; Skin and Cancer Associates, Plantation, Florida.
  • Chen CJ; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Marghoob AA; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
JAMA Dermatol ; 156(8): 882-890, 2020 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-32459294
ABSTRACT
Importance Basal cell carcinoma (BCC) is the most common skin cancer. Dermoscopic imaging has improved diagnostic accuracy; however, diagnosis of nonpigmented BCC remains limited to arborizing vessels, ulceration, and shiny white structures.

Objective:

To assess multiple aggregated yellow-white (MAY) globules as a diagnostic feature for BCC. Design, Setting, and

Participants:

In this retrospective, single-center, case-control study, nonpigmented skin tumors, determined clinically, were identified from a database of lesions consecutively biopsied during a 7-year period (January 1, 2009, to December 31, 2015). A subset of tumors was prospectively diagnosed, and reflectance confocal microscopy, optical coherence tomography, and histopathologic correlation were performed. Data analysis was conducted from July 1 to September 31, 2019. Exposures Investigators evaluated for the presence or absence of known dermoscopic criteria. MAY globules were defined as aggregated, white-yellow structures visualized in polarized and nonpolarized light. Main Outcomes and

Measures:

The primary outcome was the diagnostic accuracy of MAY globules for the diagnosis of BCC. Secondary objectives included the association with BCC location and subtype. Interrater agreement was estimated.

Results:

A total of 656 nonpigmented lesions from 643 patients (mean [SD] age, 63.1 [14.9] years; 381 [58.1%] male) were included. In all, 194 lesions (29.6%) were located on the head and neck. A total of 291 (44.4%) were BCCs. MAY globules were seen in 61 of 291 BCC cases (21.0%) and in 3 of 365 other diagnoses (0.8%) (P < .001). The odds ratio for diagnosis of BCC was 32.0 (96% CI, 9.9-103.2). The presence of MAY globules was associated with a diagnosis of histologic high-risk BCC (odds ratio, 6.5; 95% CI, 3.1-14.3). The structure was never seen in cases of superficial BCCs. Conclusions and Relevance The findings suggest that MAY globules may have utility as a new BCC dermoscopic criterion with a high specificity. MAY globules were negatively associated with superficial BCC and positively associated with deeper-seated, histologic, higher-grade tumor subtypes.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: JAMA Dermatol Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Chile

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: JAMA Dermatol Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Chile