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Non-Functionalized Fullerenes and Endofullerenes in Aqueous Dispersions as Superoxide Scavengers.
Mikheev, Ivan V; Sozarukova, Madina M; Proskurnina, Elena V; Kareev, Ivan E; Proskurnin, Mikhail A.
Afiliação
  • Mikheev IV; Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
  • Sozarukova MM; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 117901 Moscow, Russia.
  • Proskurnina EV; Research Centre for Medical Genetics, 115522 Moscow, Russia.
  • Kareev IE; Institute of Problems of Chemical Physics of the Russian Academy of Sciences, Chernogolovka, 142432 Moscow, Russia.
  • Proskurnin MA; Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Molecules ; 25(11)2020 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-32481516
ABSTRACT
Endohedral metal fullerene are potential nanopharmaceuticals for MRI; thus, it is important to study their effect on reactive oxygen species (ROS) homeostasis. Superoxide anion radical is one of the key ROS. The reactivity of aqueous dispersions of pristine (non-functionalized) fullerenes and Gd@C82 endofullerene have been studied with respect to superoxide in the xanthine/xanthine oxidase chemiluminescence system. It was found that C60 and C70 in aqueous dispersions react with superoxide as scavengers by a similar mechanism; differences in activity are determined by cluster parameters, primarily the concentration of available, acting molecules at the surface. Gd endofullerene is characterized by a significantly (one-and-a-half to two orders of magnitude) higher reactivity with respect to C60 and C70 and is likely to exhibit nanozyme (SOD-mimic) properties, which can be accounted for by the nonuniform distribution of electron density of the fullerene cage due to the presence of the endohedral atom; however, in the cell model, Gd@C82 showed the lowest activity compared to C60 and C70, which can be accounted for by its higher affinity for the lipid phase.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Assunto da revista: Biologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Federação Russa