Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms: STROBE, a case-control study.
Medicine (Baltimore)
; 99(23): e20546, 2020 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-32502017
ABSTRACT
Erectile dysfunction (ED) and depression are closely related. We sought to determine ED and depression were improved by tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, at 5âmg daily, in this case-control study.Participants were men aged 20 to 65 years with ED for >3 months, International Index of Erectile Function-5 (IIEF) score <21 points, and Zung Self-Rating Depression Scale (SDS) survey result >50 points who were willing to participate.On first visit (V1) and after 1 (V2) and 2 months (V3), clinical features were examined using IIEF-5 for diagnosing and evaluating ED, SDS for evaluating depression, and International Prostate Symptom Score and Quality of Life (IPSS/QoL) survey for examining lower urinary tract symptoms (LUTS). Tadalafil 5âmg was administered daily for 2 months.A total of 60 participants were an average age of 58.68 ± 6.71 years. Patient overall average IIEF was 8.76â±â5.98, showing mild ED symptoms, and total average IPSS 13.74â±â7.55 showed moderate LUTS. Average overall SDS index was 58.93â±â9.21, indicating moderate-to-severe findings. Average change in IIEF among all patients revealed significant improvement from V1 to V2 (-2.69â±â1.22, Pâ=â.03) and V1 to V3 (-4.38â±â1.20, Pâ<â0.01). IPSS also significantly improved from V1 to V3 (3.48â±â1.37, Pâ=â.01), as did SDS index (V1, V2 4.69â±â1.89, Pâ=â0.02), (V1, V3 5.43â±â1.89, Pâ<â.01). Patients with severe IIEF scores (group 1, nâ=â27) experienced significantly greater improvement in IIEF from V1 to V2 and V1 and V3, compared to those with mild-to-moderate IIEF scores. Both groups improved in SDS index from V1 to V2 and V1 to V3, with the greatest improvement between V1 and V3 for group 1 and V1 and V2 for group 2.Daily tadalafil 5âmg could be helpful for ED patients with depressive symptoms and improved LUTS and quality of life.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depressão
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Inibidores da Fosfodiesterase 5
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Tadalafila
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Disfunção Erétil
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Aspecto:
Patient_preference
Limite:
Adult
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Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2020
Tipo de documento:
Article