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The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway.
Li, Jin-Yan; Liao, Ce-Heng; Wang, Qiong; Tan, Yong-Jun; Luo, Rui; Qiu, Ye; Ge, Xing-Yi.
Afiliação
  • Li JY; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address: lijinyan@hnu.edu.cn.
  • Liao CH; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address: liaoceheng@hnu.edu.cn.
  • Wang Q; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address: qw@hnu.edu.cn.
  • Tan YJ; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address: yjtan@hnu.edu.cn.
  • Luo R; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China. Electronic address: luorui@mail.hzau.edu.cn.
  • Qiu Y; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address: qiuye@hnu.edu.cn.
  • Ge XY; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address: xyge@hnu.edu.cn.
Virus Res ; 286: 198074, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32589897
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019, COVID-19). SARS-CoV-2 is highly pathogenic in human, having posed immeasurable public health challenges to the world. Innate immune response is critical for the host defense against viral infection and the dysregulation of the host innate immune responses probably aggravates SARS-CoV-2 infection, contributing to the high morbidity and lethality of COVID-19. It has been reported that some coronavirus proteins play an important role in modulating innate immunity of the host, but few studies have been conducted on SARS-CoV-2. In this study, we screened the viral proteins of SARS-CoV-2 and found that the viral ORF6, ORF8 and nucleocapsid proteins were potential inhibitors of type I interferon signaling pathway, a key component for antiviral response of host innate immune. All the three proteins showed strong inhibition on type I interferon (IFN-ß) and NF-κB-responsive promoter, further examination revealed that these proteins were able to inhibit the interferon-stimulated response element (ISRE) after infection with Sendai virus, while only ORF6 and ORF8 proteins were able to inhibit the ISRE after treatment with interferon beta. These findings would be helpful for the further study of the detailed signaling pathway and unveil the key molecular player that may be targeted.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Proteínas Virais / NF-kappa B / Interferon beta / Proteínas do Nucleocapsídeo / Interações Hospedeiro-Patógeno / Betacoronavirus Limite: Humanos Idioma: Inglês Revista: Virus Res Assunto da revista: Virologia Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Proteínas Virais / NF-kappa B / Interferon beta / Proteínas do Nucleocapsídeo / Interações Hospedeiro-Patógeno / Betacoronavirus Limite: Humanos Idioma: Inglês Revista: Virus Res Assunto da revista: Virologia Ano de publicação: 2020 Tipo de documento: Artigo
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