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Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.
Zugman, André; Harrewijn, Anita; Cardinale, Elise M; Zwiebel, Hannah; Freitag, Gabrielle F; Werwath, Katy E; Bas-Hoogendam, Janna M; Groenewold, Nynke A; Aghajani, Moji; Hilbert, Kevin; Cardoner, Narcis; Porta-Casteràs, Daniel; Gosnell, Savannah; Salas, Ramiro; Blair, Karina S; Blair, James R; Hammoud, Mira Z; Milad, Mohammed; Burkhouse, Katie; Phan, K Luan; Schroeder, Heidi K; Strawn, Jeffrey R; Beesdo-Baum, Katja; Thomopoulos, Sophia I; Grabe, Hans J; Van der Auwera, Sandra; Wittfeld, Katharina; Nielsen, Jared A; Buckner, Randy; Smoller, Jordan W; Mwangi, Benson; Soares, Jair C; Wu, Mon-Ju; Zunta-Soares, Giovana B; Jackowski, Andrea P; Pan, Pedro M; Salum, Giovanni A; Assaf, Michal; Diefenbach, Gretchen J; Brambilla, Paolo; Maggioni, Eleonora; Hofmann, David; Straube, Thomas; Andreescu, Carmen; Berta, Rachel; Tamburo, Erica; Price, Rebecca; Manfro, Gisele G; Critchley, Hugo D; Makovac, Elena.
Afiliação
  • Zugman A; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  • Harrewijn A; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  • Cardinale EM; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  • Zwiebel H; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  • Freitag GF; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  • Werwath KE; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  • Bas-Hoogendam JM; Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands.
  • Groenewold NA; Leiden Institute for Brain and Cognition (LIBC), Leiden, The Netherlands.
  • Aghajani M; Leiden University, Institute of Psychology, Developmental and Educational Psychology, Leiden, The Netherlands.
  • Hilbert K; Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Cardoner N; Department. of Psychiatry, Amsterdam UMC/VUMC, Amsterdam, The Netherlands.
  • Porta-Casteràs D; GGZ InGeest, Department of Research & Innovation, Amsterdam, The Netherlands.
  • Gosnell S; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Salas R; Department of Mental Health, University Hospital Parc Taulí-I3PT, Barcelona, Spain.
  • Blair KS; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Blair JR; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
  • Hammoud MZ; Department of Mental Health, University Hospital Parc Taulí-I3PT, Barcelona, Spain.
  • Milad M; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Burkhouse K; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
  • Phan KL; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
  • Schroeder HK; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
  • Strawn JR; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA.
  • Beesdo-Baum K; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA.
  • Thomopoulos SI; Department of Psychiatry, New York University, New York, New York, USA.
  • Grabe HJ; Department of Psychiatry, New York University, New York, New York, USA.
  • Van der Auwera S; Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.
  • Wittfeld K; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
  • Nielsen JA; Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA.
  • Buckner R; Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA.
  • Smoller JW; Behavioral Epidemiology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • Mwangi B; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, California, USA.
  • Soares JC; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Wu MJ; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
  • Zunta-Soares GB; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Jackowski AP; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
  • Pan PM; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Salum GA; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
  • Assaf M; Department of Psychology, Harvard University, Cambridge, Massachusetts, USA.
  • Diefenbach GJ; Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
  • Brambilla P; Department of Psychology, Harvard University, Cambridge, Massachusetts, USA.
  • Maggioni E; Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
  • Hofmann D; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Straube T; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Andreescu C; Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Berta R; Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Tamburo E; Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Price R; Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Manfro GG; LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
  • Critchley HD; LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
  • Makovac E; Section on Negative Affect and Social Processes, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Hum Brain Mapp ; 2020 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-32596977
ABSTRACT
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Assunto da revista: Cérebro Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Assunto da revista: Cérebro Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos