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Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer.
Hanrahan, Aphrothiti J; Sylvester, Brooke E; Chang, Matthew T; Elzein, Arijh; Gao, Jianjiong; Han, Weiwei; Liu, Ye; Xu, Dong; Gao, Sizhi P; Gorelick, Alexander N; Jones, Alexis M; Kiliti, Amber J; Nissan, Moriah H; Nimura, Clare A; Poteshman, Abigail N; Yao, Zhan; Gao, Yijun; Hu, Wenhuo; Wise, Hannah C; Gavrila, Elena I; Shoushtari, Alexander N; Tiwari, Shakuntala; Viale, Agnes; Abdel-Wahab, Omar; Merghoub, Taha; Berger, Michael F; Rosen, Neal; Taylor, Barry S; Solit, David B.
Afiliação
  • Hanrahan AJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Sylvester BE; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Chang MT; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Elzein A; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Gao J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Han W; The Graduate Program in Pharmacology, The Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, New York.
  • Liu Y; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Xu D; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Gao SP; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, Changchun, China.
  • Gorelick AN; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, Changchun, China.
  • Jones AM; Department of Electrical Engineering and Computer Science, Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
  • Kiliti AJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Nissan MH; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Nimura CA; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Poteshman AN; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, New York.
  • Yao Z; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Gao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Hu W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Wise HC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Gavrila EI; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Shoushtari AN; Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Tiwari S; Center for Mechanism-Based Therapeutics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Viale A; Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Abdel-Wahab O; Center for Mechanism-Based Therapeutics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Merghoub T; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Berger MF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Rosen N; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Taylor BS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Solit DB; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Cancer Res ; 80(19): 4233-4243, 2020 10 01.
Article em En | MEDLINE | ID: mdl-32641410
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benchmarking / Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benchmarking / Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos