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Zoledronic acid sequential therapy could avoid disadvantages due to the discontinuation of less than 3-year denosumab treatment.
Kondo, Hideomi; Okimoto, Nobukazu; Yoshioka, Toru; Akahoshi, Shojiro; Fuse, Yoshifumi; Ogawa, Takayuki; Okazaki, Yuichi; Katae, Yuji; Tsukamoto, Manabu; Yamanaka, Yoshiaki; Kawasaki, Makoto; Sakai, Akinori.
Afiliação
  • Kondo H; Department of Orthopaedic Surgery, Obase Hospital, 1598 Aratsu Kanda-machi, Miyako-gun, 800-0344, Fukuoka, Japan. kondo_osho@yahoo.co.jp.
  • Okimoto N; Okimoto Clinic, Kure, Japan.
  • Yoshioka T; Department of Orthopaedic Surgery, Shimura Hospital, Hiroshima, Japan.
  • Akahoshi S; Department of Orthopaedic Surgery, Obase Hospital, 1598 Aratsu Kanda-machi, Miyako-gun, 800-0344, Fukuoka, Japan.
  • Fuse Y; Department of Orthopaedic Surgery, Saka Midorii Hospital, Hiroshima, Japan.
  • Ogawa T; Department of Orthopaedic Surgery, Kaisei General Hospital, Sakaide, Japan.
  • Okazaki Y; Department of Orthopaedic Surgery, Tobata General Hospital, Kitakyushu, Japan.
  • Katae Y; Katae Orthopaedic and Rheumatology Clinic, Kitakyushu, Japan.
  • Tsukamoto M; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Yamanaka Y; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Kawasaki M; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Sakai A; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J Bone Miner Metab ; 38(6): 894-902, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32656645
ABSTRACT

INTRODUCTION:

Rapid descent in bone mineral density (BMD) and ascent in bone turnover marker (BTM) occur within the short period following denosumab (Dmab) discontinuation. In addition, the incidence of vertebral fracture also rises within the short period. The purpose of this study is to investigate the effects of sequential therapy using zoledronic acid (ZOL) on any adverse events after Dmab discontinuation. MATERIALS AND

METHODS:

This study was a multicenter retrospective observational study, and the subjects were osteoporosis patients who visited our institutions between 2013 and 2018. We performed sequential therapy using ZOL for 30 patients who had difficulty continuing Dmab, due to physical or social reasons, and investigated the fracture incidence and BMD/BTM changes at 4 time points (at the start of Dmab, the start of ZOL, 6 months after ZOL and 12 months after ZOL).

RESULTS:

No new vertebral/nonvertebral fractures were observed at each time point after switching from Dmab to ZOL in any of the 30 patients. The BMD/BTM changes were evaluated in 18 of the 30 cases, since all data of lumbar/femoral neck BMDs and TRACP-5b at 4 time points was only available in 18 cases. BMDs significantly increased at each time point compared with that at the start of Dmab. Serum TRACP-5b significantly decreased at each time point compared with that at the start of Dmab.

CONCLUSION:

It was suggested that sequential therapy using ZOL could suppress the decrease of BMD, and increase of BTM, if the period of Dmab administration was less than 3 years.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Suspensão de Tratamento / Denosumab / Ácido Zoledrônico Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Bone Miner Metab Assunto da revista: Metabolismo Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Japão

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Suspensão de Tratamento / Denosumab / Ácido Zoledrônico Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Bone Miner Metab Assunto da revista: Metabolismo Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Japão
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