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Factors predicting survival in thick melanoma: Do all thick melanomas have the same prognosis?
Han, Dale; Han, Gang; Morrison, Steven; Leong, Stanley P; Kashani-Sabet, Mohammed; Vetto, John; White, Richard; Schneebaum, Schlomo; Pockaj, Barbara; Mozzillo, Nicola; Sondak, Vernon K; Zager, Jonathan S.
Afiliação
  • Han D; Division of Surgical Oncology, Oregon Health & Science University, Portland, OR. Electronic address: handal@ohsu.edu.
  • Han G; Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX.
  • Morrison S; Division of Surgical Oncology, Oregon Health & Science University, Portland, OR.
  • Leong SP; Department of Surgery, California Pacific Medical Center and Research Institute, San Francisco, CA.
  • Kashani-Sabet M; Department of Dermatology, California Pacific Medical Center and Research Institute, San Francisco, CA.
  • Vetto J; Division of Surgical Oncology, Oregon Health & Science University, Portland, OR.
  • White R; Levine Cancer Institute, Carolinas Medical Center, Atrium Health, Charlotte, NC.
  • Schneebaum S; Department of Surgery, Tel-Aviv Sourasky Medical Center, Israel.
  • Pockaj B; Department of Surgery, Mayo Clinic, Phoenix, AZ.
  • Mozzillo N; Department of Melanoma and Soft Tissues, Instituto Tumori Napoli Fondazione G. Pascale, Italy.
  • Sondak VK; Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL.
  • Zager JS; Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL.
Surgery ; 168(3): 518-526, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32669204
ABSTRACT

BACKGROUND:

It is unknown whether all thick melanomas share the same prognostic features. We present a large, multi-institutional study on thick melanoma, evaluating for factors prognostic of survival.

METHODS:

We queried the database of the Sentinel Lymph Node Working Group for patients with thick melanoma (>4 mm) who had a sentinel lymph node biopsy from 1993 to 2018. Clinicopathologic characteristics were correlated with overall survival.

RESULTS:

There were 1,235 patients with a median follow-up of 28 months. Median thickness was 5.9 mm, with 713, 356, and 166 cases having a thickness of >4 to 6, >6 to 10, and >10 mm, respectively. Ulceration was seen in 51.2% of cases, while sentinel lymph node metastases were seen in 439 of 1,235 (35.5%) cases. For melanomas >4 to 6 mm, age, thickness, ulceration, lymphovascular invasion, and sentinel lymph node metastasis were correlated with overall survival (all P < .05), but for melanomas >6 to 10 mm, only sex and sentinel lymph node metastasis were prognostic of overall survival (both P < .05). For melanomas >10 mm, only sentinel lymph node metastasis predicted overall survival on multivariable analyses (P < .05).

CONCLUSION:

Prognostic markers of overall survival for thick melanoma include thickness, ulceration, and sentinel lymph node metastasis, but also include other unique factors such as lymphovascular invasion. Moreover, certain prognostic markers for survival are associated with different subgroups of thick melanoma, which vary based on thickness group.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pele / Neoplasias Cutâneas / Procedimentos Cirúrgicos Dermatológicos / Melanoma / Recidiva Local de Neoplasia Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Surgery Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pele / Neoplasias Cutâneas / Procedimentos Cirúrgicos Dermatológicos / Melanoma / Recidiva Local de Neoplasia Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Surgery Ano de publicação: 2020 Tipo de documento: Artigo
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