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Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.
Hagenaars, Saskia P; Coleman, Jonathan R I; Choi, Shing Wan; Gaspar, Héléna; Adams, Mark J; Howard, David M; Hodgson, Karen; Traylor, Matthew; Air, Tracy M; Andlauer, Till F M; Arolt, Volker; Baune, Bernhard T; Binder, Elisabeth B; Blackwood, Douglas H R; Boomsma, Dorret I; Campbell, Archie; Cearns, Micah; Czamara, Darina; Dannlowski, Udo; Domschke, Katharina; de Geus, Eco J C; Hamilton, Steven P; Hayward, Caroline; Hickie, Ian B; Hottenga, Jouke Jan; Ising, Marcus; Jones, Ian; Jones, Lisa; Kutalik, Zoltan; Lucae, Susanne; Martin, Nicholas G; Milaneschi, Yuri; Mueller-Myhsok, Bertram; Owen, Michael J; Padmanabhan, Sandosh; Penninx, Brenda W J H; Pistis, Giorgio; Porteous, David J; Preisig, Martin; Ripke, Stephan; Shyn, Stanley I; Sullivan, Patrick F; Whitfield, John B; Wray, Naomi R; McIntosh, Andrew M; Deary, Ian J; Breen, Gerome; Lewis, Cathryn M.
Afiliação
  • Hagenaars SP; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Coleman JRI; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Choi SW; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Gaspar H; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Adams MJ; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Howard DM; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Hodgson K; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Traylor M; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Air TM; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Andlauer TFM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Arolt V; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Baune BT; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Binder EB; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Blackwood DHR; Discipline of Medicine, University of Adelaide, Adelaide, Australia.
  • Boomsma DI; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Campbell A; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Cearns M; Department of Psychiatry, University of Münster, Münster, Germany.
  • Czamara D; Department of Psychiatry, University of Münster, Münster, Germany.
  • Dannlowski U; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Australia.
  • Domschke K; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
  • de Geus EJC; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Hamilton SP; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Hayward C; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Hickie IB; Netherlands Twin Register, Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
  • Hottenga JJ; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Ising M; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Australia.
  • Jones I; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Jones L; Department of Psychiatry, University of Münster, Münster, Germany.
  • Kutalik Z; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Lucae S; Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Martin NG; Netherlands Twin Register, Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
  • Milaneschi Y; Department of Psychiatry, Kaiser Permanente Northern California, San Francisco, California, USA.
  • Mueller-Myhsok B; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Owen MJ; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Padmanabhan S; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
  • Penninx BWJH; Netherlands Twin Register, Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
  • Pistis G; Max Planck Institute of Psychiatry, Munich, Germany.
  • Porteous DJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
  • Preisig M; Department of Psychological Medicine, University of Worcester, Worcester, UK.
  • Ripke S; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
  • Shyn SI; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Sullivan PF; Max Planck Institute of Psychiatry, Munich, Germany.
  • Whitfield JB; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Wray NR; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience Research Institutes, Amsterdam UMC/Vrije Universiteit, Amsterdam, The Netherlands.
  • McIntosh AM; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Deary IJ; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Breen G; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK.
  • Lewis CM; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Am J Med Genet B Neuropsychiatr Genet ; 183(6): 309-330, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32681593
ABSTRACT
It is imperative to understand the specific and shared etiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic association between major depression and cardio-metabolic traits and if this association is stratified by age at onset for major depression. Polygenic risk scores analysis and linkage disequilibrium score regression was performed to examine whether differences in shared genetic etiology exist between depression case control status (N cases = 40,940, N controls = 67,532), earlier (N = 15,844), and later onset depression (N = 15,800) with body mass index, coronary artery disease, stroke, and type 2 diabetes in 11 data sets from the Psychiatric Genomics Consortium, Generation Scotland, and UK Biobank. All cardio-metabolic polygenic risk scores were associated with depression status. Significant genetic correlations were found between depression and body mass index, coronary artery disease, and type 2 diabetes. Higher polygenic risk for body mass index, coronary artery disease, and type 2 diabetes was associated with both early and later onset depression, while higher polygenic risk for stroke was associated with later onset depression only. Significant genetic correlations were found between body mass index and later onset depression, and between coronary artery disease and both early and late onset depression. The phenotypic associations between major depression and cardio-metabolic traits may partly reflect their overlapping genetic etiology irrespective of the age depression first presents.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional Idioma: Inglês Revista: Am J Med Genet B Neuropsychiatr Genet Assunto da revista: Genética Médica / Neurologia / Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Reino Unido

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional Idioma: Inglês Revista: Am J Med Genet B Neuropsychiatr Genet Assunto da revista: Genética Médica / Neurologia / Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Reino Unido
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