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Poincianella pyramidalis (Tul) L.P. Queiroz: A review on traditional uses, phytochemistry and biological-pharmacological activities.
de Sousa, Leide Maria Soares; Santos, Brenda N G; Medeiros, Maria das Graças F; Lima, Izabela B C; Santos-Filho, Francisco Soares; Santana, Ana Cristina S G V; Moreno, Lina Clara G A I; Nunes, Lívio C C.
Afiliação
  • de Sousa LMS; Postgraduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil.
  • Santos BNG; Postgraduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil.
  • Medeiros MDGF; Postgraduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil.
  • Lima IBC; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.
  • Santos-Filho FS; Center of Natural Sciences, State University of Piauí, Teresina, Brazil.
  • Santana ACSGV; Department of Pharmacy, Federal University of Piauí, Teresina, Brazil.
  • Moreno LCGAI; Postgraduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil; Immunophatology Keizo-Asami Laboratory, Federal University of Pernambuco, Recife, Brazil. Electronic address: linaclaramoreno@gmail.com.
  • Nunes LCC; Postgraduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.
J Ethnopharmacol ; 264: 113181, 2021 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-32687960
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Poincianella pyramidalis (Tul.) LP Queiroz (Fabaceae) is an endemic tree in the Northeast of Brazil. Its flowers, leaves, stem bark and root have been used over the years to treat infections, abdominal pain, inflammation, diarrhea, heartburn, and dyspepsia. AIM OF THE STUDY The present study is a critical assessment of the state-of-the-art concerning traditional uses, phytochemistry, pharmacology and toxicology of P. pyramidalis performed through the application of a robust research strategy to explore the therapeutic potential of P. pyramidalis extracts and isolated compounds for the treatment of human disorders. MATERIALS AND

METHODS:

Information related to this review was systematically collected from scientific literature databases for P. pyramidalis, including papers and patents (PubMed, Science Direct, Scopus, Web of Science, Google scholar, INPI, WIPO, EPO and USPTO), published books (e.g. Plantas Forrageiras das Caatingas), dissertations and theses. Plant taxonomy has been confirmed in the "The Plant List" database (www.theplantlist.org).

RESULTS:

Phytochemical analysis of P. pyramidalis shows several constituents such as flavonoids, triterpenoids and phenylpropanoids. The extract and isolated constituents exhibited a wide range of in vitro and in vivo pharmacological effects including antimicrobial, antinociceptive, anti-inflammatory, gastroprotective and neuroprotective activities. In addition, toxicity studies showed that the administration of P. pyramidalis extract was safe in non-pregnant rats but displayed teratogenic effects in rats and goats. On the other hand, the search in patent databases reported a single filing, which highlights the disparity between a large number of published scientific articles versus the almost nonexistent filing of patents. This fact evidences a still little explored technological potential of the species.

CONCLUSION:

P. pyramidalis represents an important therapeutic resource for the population from the Northeast of Brazil. Pharmacological studies confirmed the effectiveness of the extract or isolated compounds in the treatment of various pathologies traditionally treated with P. pyramidalis. The authors emphasize the need for in-depth research and future clinical trials in order to investigate the clinical efficacy and safety of P. pyramidalis.
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Diarreia Base de dados: MEDLINE Idioma: Inglês Revista: J Ethnopharmacol Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Brasil

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Diarreia Base de dados: MEDLINE Idioma: Inglês Revista: J Ethnopharmacol Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Brasil