Your browser doesn't support javascript.
loading
Structural study of L-ascorbic acid 2-phosphate magnesium, a raw material in cell and tissue therapy.
Xu, Xiaolong; Wozniczka, Magdalena; Van Hecke, Kristof; Buyst, Dieter; Mara, Dimitrije; Vervaet, Chris; Herman, Karen; Wynendaele, Evelien; Deconinck, Eric; De Spiegeleer, Bart.
Afiliação
  • Xu X; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
  • Wozniczka M; Department of Physical and Biocoordination Chemistry, Faculty of Pharmacy, Medical University of Lódz, Muszynskiego 1, 90-151, Lódz, Poland.
  • Van Hecke K; Department of Chemistry, Ghent University, Krijgslaan 281, 9000, Ghent, Belgium.
  • Buyst D; Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, 9000, Ghent, Belgium.
  • Mara D; Department of Chemistry, Ghent University, Krijgslaan 281, 9000, Ghent, Belgium.
  • Vervaet C; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
  • Herman K; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
  • Wynendaele E; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
  • Deconinck E; Section of Medicines and Health Products, Scientific Direction Chemical and Physical Health Risks, Sciensano, Juliette Wytsmanstreet 14, 1050, Brussels, Belgium.
  • De Spiegeleer B; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. Bart.DeSpiegeleer@UGent.be.
J Biol Inorg Chem ; 25(6): 875-885, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32719971
ABSTRACT
L-ascorbic acid 2-phosphate magnesium (APMg) salt is a vitamin C derivative frequently used as a raw material in cell and tissue therapy. APMg is not only used as a replacement of the unstable ascorbate, but also shows additional cell-biological functionalities. However, its unknown structural characteristics hamper the mechanistic elucidation of its biological role. Therefore, different techniques were applied for APMg structure characterization. Firstly, the stoichiometric composition was characterized by its solvent, ligand and magnesium content. No crystals of APMg could be obtained; however, a single crystal of APNa, the sodium salt of l-ascorbic acid 2-phosphate, was successfully obtained and its crystal structure was elucidated. FT-IR was applied to further clarify the structure of solid APMg. Finally, the structure of APMg in aqueous solution was explored by potentiometric titration as well as FT-IR.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Biol Inorg Chem Assunto da revista: Bioquímica Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Bélgica

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Biol Inorg Chem Assunto da revista: Bioquímica Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Bélgica